Effect of some psychoactive agents on pentobarbitone anaesthesia in rats.

Kato and Chiesara (7) reported that many centrally active agents may produce tolerance to barbiturates as a result of induction of liver microsomal enzymes involved in drug metabolism Haloperidol and promethazine have also been reported to influence the enzyme activity (6). As there is lack of information concerning the effect of various psycho-active agents on metabolic mechanisms, it was thought of interest to study the influence of some of the commonly used agents on pantobarbitone anaesthetic time and if possible to attempt to correlate the data obtained with the results on enzyme activity reported in the literature.